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Cynomolgus FGF R2 (IIIb) protein, His Tag

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分子别名(Synonym)

FGF R2 (IIIb),FGFR2B,FGFR2

表达区间及表达系统(Source)

Cynomolgus FGFR2 (IIIb), His Tag (FGB-C52H6) is expressed from human 293 cells (HEK293). It contains AA Pro 154 - Lys 368 (Accession # A0A2K5TL84-1).

Predicted N-terminus: Pro 154

蛋白结构(Molecular Characterization)

Online-Res(Pro 154 - Lys 368) A0A2K5TL84-1

This protein carries a polyhistidine tag at the C-terminus.

The protein has a calculated MW of 25.9 kDa.

内毒素(Endotoxin)

制剂(Formulation)

Please contact us for detailed information.

Contact us for customized product form or formulation.

重构方法(Reconstitution)

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

存储(Storage)

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:

  1. -20°C to -70°C for 12 months in lyophilized state;
  2. -70°C for 3 months under sterile conditions after reconstitution.
 

背景(Background)

Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation, migration and apoptosis, and in the regulation of embryonic development. Required for normal embryonic patterning, trophoblast function, limb bud development, lung morphogenesis, osteogenesis and skin development. Plays an essential role in the regulation of osteoblast differentiation, proliferation and apoptosis, and is required for normal skeleton development. Promotes cell proliferation in keratinocytes and immature osteoblasts, but promotes apoptosis in differentiated osteoblasts. Phosphorylates PLCG1, FRS2 and PAK4. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. FGFR2 signaling is down-regulated by ubiquitination, internalization and degradation. Mutations that lead to constitutive kinase activation or impair normal FGFR2 maturation, internalization and degradation lead to aberrant signaling. Over-expressed FGFR2 promotes activation of STAT1.

 

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FGF R2 (IIIb)靶点信息
英文全称:Fibroblast growth factor receptor 2
中文全称:成纤维细胞生长因子受体-2
种类:Homo sapiens
上市药物数量:6详情
临床药物数量:18详情
最高研发阶段:批准上市
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