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新冠疫苗研发核心工具

2019年12月,一种新型的冠状病毒SARS-CoV-2开始在全球范围内快速传播,造成了全球性的新冠疫情大流行,导致(截止到2021年11月)超过2亿人确诊感染新型冠状病毒,近500万人死亡,给全球人民的生命健康带来巨大威胁的同时,对世界各国的社会稳定和经济发展造成了深远的影响。
不仅如此,在新冠疫情肆虐全球的过程中,不断出现的新冠病毒变异毒株更是使得挑战升级。目前,世界卫生组织(WHO)已将具有更强传播能力或免疫逃逸能力的4种变异毒株列为“需要特别关注的突变毒株”(VOCs),包括Alpha(B.1.1.7)、Beta(B.1.351)、Gamma(P.1)及Delta(B.1.617.2)。其中,Beta和Gamma毒株具有极强的免疫逃逸能力,而Alpha和Delta变异毒株具有极强的传播能力和较强的免疫逃逸能力。目前,在Delta变异毒株逐渐成为全球主要流行毒株的同时,如Lambda(C.37)、Mu(B.1.621)、C.1.2的新型变异毒株也不断涌现。

>>> 点击查看新冠突变抗原蛋白及相关亚搏手机版app下载足球

面对来势汹汹的新冠疫情,疫苗作为防控传染病最有效且最经济的公共健康措施之一, 开发可高效预防新型冠状病毒感染及传播的疫苗并持续评估其对流行突变株的有效性具有重要意义。
新冠疫苗研发技术路线
在疫情爆发后仅1年多的时间里,全球各科研单位和疫苗公司紧密合作、共同努力,成功研制出包括灭活病毒疫苗、重组蛋白疫苗、腺病毒载体疫苗、mRNA疫苗等多款新冠疫苗并获得紧急使用授权,在全球范围内进行接种。另据不完全统计,目前全球共有300余种新冠候选疫苗处于临床前及临床阶段试验,接下来仍将有多种新冠疫苗获批使用。
新冠疫苗技术路线
新冠疫苗研发技术路线
国家药品监督管理局药品审评中心于2020年8月发布了一系列《新型冠状病毒预防用疫苗研发技术指导原则(试行)》,从药学研究、非临床研究到临床研究全流程,明确了灭活疫苗、基因工程重组疫苗、病毒载体类疫苗、DNA疫苗及mRNA疫苗等不同技术路线评价过程中的关键指标。
新冠疫苗开发流程
生产/质量控制

(1)疫苗抗原含量检测

灭活疫苗/重组蛋白疫苗:SDS-PAGE,MS,ELISA;

病毒载体疫苗/核酸疫苗:Western Blot,FACS;

(2)疫苗抗原活性检测

重组蛋白疫苗:ELISA,SPR,BLI

(3)疫苗生物效价检测

动物血清总抗体检测:间接法ELISA

临床前药效学研究

(1)疫苗生物效价研究

①体内效力试验:

★体液免疫:

Ⅰ动物血清总抗体检测:间接法ELISA

Ⅱ动物血清中和抗体检测:cVNT,pVNT,sVNT(竞争法ELISA)

★细胞免疫:Elispot

②体外效价检测: 疫苗抗原含量:双抗夹心ELISA

③动物保护性试验:动物攻毒保护试验

(2)毒理研究

①体液免疫(抗体亚型检测):间接法ELISA

②细胞免疫(特异性T细胞及细胞因子检测):Elispot

早期临床试验(I-II期)
关键性注册临床试验(III期)

(1)疫苗生物效价研究

①体内效力试验:

★体液免疫:

Ⅰ人体血清总抗体检测:间接法ELISA

Ⅱ人体血清中和抗体检测:cVNT,pVNT,sVNT(竞争法ELISA)

★细胞免疫:Elispot

②体外效价检测:

★疫苗抗原含量:双抗夹心法ELISA

③动物保护性试验:动物攻毒保护试验

(2)毒理研究

①体液免疫(抗体亚型检测):间接法ELISA

②细胞免疫(特异性T细胞及细胞因子检测):Elispot

(3) 免疫持久性 (III期临床试验)

①人体血清总抗体检测:间接法ELISA

②人体血清中和抗体检测:CVNT, pVNT, sVNT(竞争法ELISA)

>>> 点击下载《新型冠状病毒预防用疫苗研发技术指导原则(试行)》系列指导原则

疫苗研发与临床及临床前研究解决方案
为助力新冠疫苗研发,加速疫苗上市进程,ACROBiosystems(百普赛斯)持续关注新冠疫情发展,开发了针对新冠野生型及Alpha (B.1.1.7)、Beta (B.1.351)、Gamma (P.1)、Delta (B.1.617.2)、Lambda (C.37)、Mu (B.1.621)等VOCs及VOIs流行突变株的系列相关亚搏手机版app下载足球,提供高纯度高稳定性的抗原、高活性广谱抗体、突变特异性ELISA试剂盒及高效便捷的预偶联磁珠亚搏手机版app下载足球,力求为新冠疫苗研发到上市前的全流程提供相应解决方案。
疫苗抗原含量检测
  • 天然Pre-fusion状态三聚体Spike蛋白
  • RBD/S trimer抗原定量检测试剂盒

SDS-PAGE及MS抗原检测的高纯度标品——天然Pre-fusion状态三聚体Spike蛋白

引入6P突变使Spike蛋白稳定在融合前构象,接近蛋白天然构象
经SDS-PAGE和SEC-MALS及负染电镜技术验证,Spike三聚体纯度>90%
提供所有VOCs及其他热门突变株亚搏手机版app下载足球,突变位点与真实毒株一致
亚搏手机版app下载足球列表
新冠种属 货号 突变位点 标签 订购/预购
SARS-CoV-2
Wild Type
SPN-C52H9 NA His Tag

订购

SPN-C82E9 NA His & Avitag™

订购

SARS-CoV-2
   OmicronNEW
B.1.1.529
SPN-C52Hz A67V, HV69-70del, T95I, G142D, VYY143-145del, N211del, L212I, ins214EPE, G339D, S371L, S373P, S375F, K417N, N440K, G446S, S477N, T478K, E484A, Q493R, G496S, Q498R, N501Y, Y505H, T547K, D614G, H655Y, N679K, P681H, N764K, D796Y, N856K, Q954H, N969K, L981F His Tag

订购

SPN-C82Ee A67V, HV69-70del, T95I, G142D, VYY143-145del, N211del, L212I, ins214EPE, G339D, S371L, S373P, S375F, K417N, N440K, G446S, S477N, T478K, E484A, Q493R, G496S, Q498R, N501Y, Y505H, T547K, D614G, H655Y, N679K, P681H, N764K, D796Y, N856K, Q954H, N969K, L981F His Tag & Avi Tag

订购

SARS-CoV-2
Delta | B.1.617.2
SPN-C52He T19R, G142D, EF156-157del, R158G, L452R, T478K, D614G, P681R, D950N His Tag

订购

SPN-CR2H7 T19R, G142D, EF156-157del, R158G, L452R, T478K, D614G, P681R, D950N His Tag

订购

SPN-C82Ec T19R, G142D, EF156-157del, R158G, L452R, T478K, D614G, P681R, D950N His & Avitag™

订购

SARS-CoV-2
Delta Plus | AY.1 | AY.2 | AY.3
SPN-C52Ht T19R, V70F, FR157-158Del, A222V, W258L, K417N, L452R, T478K, D614G, P681R, D950N His Tag

订购

SPN-C82Ei T19R, V70F, FR157-158Del, A222V, W258L, K417N, L452R, T478K, D614G, P681R, D950N His & Avitag™

订购

SARS-CoV-2
Lambda | C.37
SPN-C52Hs G75V, T76I, SYLTPGD 247-253 del, L452Q, F490S, D614G, T859N His Tag

订购

SPN-C82Eh G75V, T76I, SYLTPGD 247-253 del, L452Q, F490S, D614G, T859N His & Avitag™

订购

SARS-CoV-2
C.1.2
SPN-C52Hb C136F, Y144del, R190S, D215G, LA242-243del, Y449H, E484K, N501Y, D614G, H655Y, N679K, T716I, T859N His Tag

订购

SPN-C82Eq C136F, Y144del, R190S, D215G, LA242-243del, Y449H, E484K, N501Y, D614G, H655Y, N679K, T716I, T859N His & Avitag™

订购

SARS-CoV-2
Mu | B.1.621
SPN-C52Ha T95I, Y144S, Y145N, R346K, E484K, N501Y, D614G, P681H, D950N His Tag

订购

SPN-C82Ek T95I, Y144S, Y145N, R346K, E484K, N501Y, D614G, P681H, D950N His & Avitag™

订购

SARS-CoV-2
Alpha | B.1.1.7
SPN-C52Hp N501Y, D614G His Tag

订购

SPN-C52H6 HV69-70del, Y144del, N501Y, A570D, D614G, P681H, T716I, S982A, D1118H His Tag

订购

SPN-C82E5 HV69-70del, Y144del, N501Y, A570D, D614G, P681H, T716I, S982A, D1118H His & Avitag™

订购

SARS-CoV-2
Beta | B.1.351
SPN-C52Hk L18F, D80A, D215G, 242-244del, R246I, K417N, E484K, N501Y, D614G, A701V His Tag

订购

SPN-C82E4 L18F, D80A, D215G, 242-244del, R246I, K417N, E484K, N501Y, D614G, A701V His & Avitag™

订购

SPN-C52Hm K417N, D614G His Tag

订购

SPN-C52Hq E484K, D614G His Tag

订购

SARS-CoV-2
Gamma | P.1
SPN-C52Hg L18F, T20N, P26S, D138Y, R190S, K417T, E484K, N501Y, D614G, H655Y, T1027I, V1176F His Tag

订购

SPN-C82E6 L18F, T20N, P26S, D138Y, R190S, K417T, E484K, N501Y, D614G, H655Y, T1027I, V1176F His & Avitag™

订购

SPN-C52Hn K417T, D614G His Tag

订购

SPN-C52Hq E484K, D614G His Tag

订购

SARS-CoV-2
Kappa | B.1.617.1
SPN-C52Hr T95I, G142D, E154K, L452R, E484Q, D614G, P681R, Q1071H His Tag

订购

SPN-C82E7 T95I, G142D, E154K, L452R, E484Q, D614G, P681R, Q1071H His & Avitag™

订购

SARS-CoV-2
B.1.620
SPN-C52Hh P26S, HV69-70del, V126A, Y144del, LLA241-243del, H245Y, S477N, E484K, D614G, P681H, T1027I, D1118H His Tag

订购

SPN-C82Ed P26S, HV69-70del, V126A, Y144del, LLA241-243del, H245Y, S477N, E484K, D614G, P681H, T1027I, D1118H His & Avitag™

订购

SARS-CoV-2
D614G
SPN-C52H3 D614G His Tag

订购

SPN-CR2H3 D614G His Tag

订购

SPN-C82E3 D614G His & Avitag™

订购

SPN-C52Hm K417N, D614G His Tag

订购

SPN-C52Hn K417T, D614G His Tag

订购

验证数据
验证数据
结构鉴定数据(SDS-PAGE & SEC-MALS & 负染电镜)

The purity of SARS-CoV-2 S protein, His Tag, Super stable trimer (Cat. No. SPN-C52H9) is more than 90% verified by SDS-PAGE under reducing (R) condition. The molecular weight was around 550-660 kDa confirmed by SEC-MALS. The particles are similar in size and appearance to SARS-CoV-2 trimers reported in published literature verified by negative stain electron micrography.

Protocol

活性验证数据

Immobilized Anti-SARS-CoV-2 Neutralizing Antibody, Human IgG1 (Cat. No. SAD-S35) at 1 μg/mL (100 μL/well) can bind SARS-CoV-2 S protein, His Tag, Super stable trimer (Cat. No. SPN-C52H9) with a linear range of 0.3-10 ng/mL.

Protocol

活性验证数据

用不同的SARS-CoV-2 S protein检测康复病人血清,其中SARS-CoV-2 S protein, His Tag, Super stable trimer (Cat. No. SPN-C52H9)信噪比较高。

Protocol

高效获取抗原含量指标——RBD/S trimer抗原定量检测试剂盒(双抗体夹心法ELISA)

满足各种疫苗对于不同灵敏度需求的检测
试剂盒中抗体对可识别不同突变株抗原且活性不变
经客户验证,实验数据稳定,可对疫苗量产进行定量监控
亚搏手机版app下载足球列表
货号 亚搏手机版app下载足球描述 检测样本 订购/预购
RAS-A010 SARS-CoV-2 Nucleocapsid Protein Titer Assay Kit Vaccine samples

订购

RAS-A020 SARS-CoV-2 Spike Protein Titer Assay Kit Vaccine samples

订购

RAS-A021 SARS-CoV-2 Spike RBD Titer Assay Kit Vaccine samples

订购

RAS-A039 SARS-CoV-2 Spike Protein ELISA Kit (For Vaccine Development) Vaccine samples

订购

RAS-A050 SARS-CoV-2 Spike RBD ELISA Kit (For Vaccine Development) Vaccine samples

订购

RAS-A071 SARS-CoV-2 Spike Trimer (B.1.1.529) ELISA Kit (For Vaccine Development) Vaccine samples

订购

RAS-A072 SARS-CoV-2 Spike RBD (B.1.1.529) ELISA Kit (For Vaccine Development) Vaccine samples

订购

验证数据

试剂盒检测Spike Protein定量范围:781-3.05pg/mL

试剂盒检测Spike Protein定量范围:625-4.88ng/mL

>>> 相关蛋白亚搏手机版app下载足球纯度经MALS验证,活性经体外结合实验和细胞水平验证,点击查看详情。

>>> 如果您希望ACRO开发更多类型的SARS-CoV-2(COVID-19)的亚搏手机版app下载足球或有定制化的亚搏手机版app下载足球、服务需求,请点击提议

疫苗抗原活性检测
  • 高质量ACE2受体蛋白
  • 抗原与ACE2亲和力服务

抗原活性验证天然二聚体配体——高质量ACE2受体蛋白

提供His、His, Avitag™、Fc、Fc, Avitag™等不同标签
覆盖Human、Mouse、Cynomolgus、Rat、Paguma larvata不同种属
生物素化及非生物素化受体蛋白可选择
高纯度高结合活性经验证
亚搏手机版app下载足球列表
分子 货号 种属 标签 宿主 亚搏手机版app下载足球描述 订购/预购
ACE2 AC2-H82E6 Human His Tag & Avi Tag HEK293 Biotinylated Human ACE2 / ACEH Protein, His,Avitag™ (MALS verified)

订购

AC2-H5257 Human Fc Tag HEK293 Human ACE2 / ACEH Protein, Fc Tag (MALS verified)

订购

AC2-H82F9 Human Fc Tag & Avi Tag HEK293 Biotinylated Human ACE2 / ACEH Protein, Fc,Avitag™

订购

AC2-H52H8 Human His Tag HEK293 Human ACE2 / ACEH Protein, His Tag (MALS verified)

订购

AC2-H5205 Human Mouse IgG1 Fc Tag HEK293 Human ACE2 / ACEH Protein, Mouse IgG1 Fc Tag (MALS verified)

订购

AC2-H82E8 Human His Tag & Avi Tag HEK293 Biotinylated Human ACE2 / ACEH Protein, His,Avitag™

订购

AC2-P5248 Paguma larvata His Tag HEK293 Paguma larvata ACE2 / ACEH Protein, His Tag (SPR verified)

订购

AC2-M5248 Mouse His Tag HEK293 Mouse ACE2 / ACEH Protein, His Tag (MALS verified)

订购

AC2-C52H7 Cynomolgus His Tag HEK293 Cynomolgus ACE2 / ACEH Protein, His Tag

订购

AC2-R5246 Rat His Tag HEK293 Rat ACE2 / ACEH Protein, His Tag (MALS verified)

订购

Neuropilin-1 NR1-H5228 Human His Tag HEK293 Human Neuropilin-1 / NRP1 / CD304 Protein, His Tag

订购

NR1-H5252 Human Fc Tag HEK293 Human Neuropilin-1 / NRP1 / CD304 Protein, Fc Tag

订购

NR1-H82E3 Human His Tag & Avi Tag HEK293 Biotinylated Human Neuropilin-1 / NRP1 / CD304 Protein, His,Avitag™

订购

NR1-M5254 Mouse Mouse IgG2a Fc Tag HEK293 Mouse Neuropilin-1 / NRP1 / CD304 Protein, Mouse IgG2a Fc Tag, low endotoxin

订购

ASGR1 AS1-H5253 Human Fc Tag HEK293 Human ASGR1/ASGPR1 Protein, Fc Tag

订购

KREMEN1 KR1-H5253 Human Fc Tag HEK293 Human Kremen-1 protein, Fc Tag

订购

验证数据
活性验证数据

Immobilized SARS-CoV-2 S1 protein, His Tag (Cat. No. S1N-C52H3) at 2 μg/mL (100 μL/well) can bind Biotinylated Human ACE2, His,Avitag (Cat. No. AC2-H82E6) with a linear range of 2-20 ng/mL (QC tested).

Protocol

Human ACE2, Fc Tag (Cat. No. AC2-H5257) captured on CM5 chip via Anti-human IgG Fc antibodies surface can bind recombinant SARS-CoV-2 Spike vaccine with an affinity constant of 16.9 nM as determined in a SPR assay (Biacore T200).

Protocol

输出疫苗抗原与ACE2结合的全面性研究——抗原与ACE2亲和力服务

可进行疫苗抗原与ACE2结合的快慢、强弱及机理等多方面的定量和定性的全面分析
提供多种优质抗原蛋白及不同验证方法(SPR、BLI等)
高标准的质量管理控制体系,数据质量满足申报要求
个性化方案及报告形式定制,最快次日即可出具报告
提供多地多平台检测服务
生物效价&免疫持久性检测
  • 抗体滴度检测
  • 中和抗体滴度检测
  • 新冠Spike蛋白萤光素酶假病毒
  • 广谱RBD蛋白中和抗体

满足疫苗开发各阶段(动物 & 人体)体内效价检测需求——S trimer/RBD/S1 IgG抗体滴度检测试剂盒(间接法ELISA)

可溯源至WHO国际标准血清 (G, NIBSC code 20/136),试剂盒标品与其相关性良好,检测数据具有实验室间可比性和标准性
提供适用于人、鼠、猴等不同种属血清抗体检测的试剂盒,满足临床前及临床实验需求
提供VOCs突变特异性IgG抗体滴度试剂盒,可用于疫苗针对突变的临床及临床前效价检测
试剂批间差小,试剂稳定
应用场景 货号 预包被抗原 检测样本 亚搏手机版app下载足球描述 订购/预购
临床前实验 RAS-T018 Spike RBD Mouse Serum Mouse Anti-SARS-CoV-2 Antibody IgG Titer Serologic Assay kit

订购

RAS-T023 Spike Trimer Mouse Serum Mouse Anti-SARS-CoV-2 Antibody IgG Titer Serologic Assay Kit (Spike Trimer)

订购

RAS-T019 Spike RBD Monkey Serum Monkey Anti-SARS-CoV-2 Antibody IgG Titer Serologic Assay kit

订购

RAS-T059

SARS-CoV-2

   OmicronNEW B.1.1.529

Mouse Serum Mouse Anti-SARS-CoV-2 (B.1.1.529) Antibody IgG Titer Serologic Assay Kit (Spike RBD)

点击预购

RAS-T060 Mouse Serum Mouse Anti-SARS-CoV-2 (B.1.1.529) Antibody IgG Titer Serologic Assay Kit (Spike Trimer)

点击预购

RAS-T061 Mouse Serum Mouse Anti-SARS-CoV-2 (B.1.1.529) Antibody IgG Titer Serologic Assay Kit (Spike S1)

点击预购

RAS-T062 Monkey Serum Monkey Anti-SARS-CoV-2 (B.1.1.529) Antibody IgG Titer Serologic Assay Kit (Spike RBD)

点击预购

RAS-T063 Monkey Serum Monkey Anti-SARS-CoV-2 (B.1.1.529) Antibody IgG Titer Serologic Assay Kit (Spike Trimer)

点击预购

RAS-T064 Monkey Serum Monkey Anti-SARS-CoV-2 (B.1.1.529) Antibody IgG Titer Serologic Assay Kit (Spike S1)

点击预购

RAS-T070 Mouse Serum SARS-CoV-2 印度突变株 Delta | B.1.617.2 (India) Mouse Anti-SARS-CoV-2 (B.1.617.2) Antibody IgG Titer Serologic Assay Kit (Spike Trimer)

订购

临床实验 RAS-T024 Spike RBD Human Serum Anti-SARS-CoV-2 Antibody IgG Titer Serologic Assay Kit (Spike RBD)

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RAS-T025 Spike Trimer Human Serum Anti-SARS-CoV-2 Antibody IgG Titer Serologic Assay Kit (Spike Trimer)

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RAS-T001 Spike S1 Human Serum Anti-SARS-CoV-2 Antibody IgG Titer Serologic Assay Kit (Spike S1)

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RAS-T008 Nucleocapsid Protein Human Serum Anti-SARS-CoV-2 Antibody IgG Titer Serologic Assay kit (Nucleocapsid Protein)

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RAS-T009 Spike RBD Human Serum Anti-SARS-CoV-2 Total Antibody Titer Serologic Assay kit (Spike RBD)

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RAS-T026 Alpha (B.1.1.7)
Spike RBD
Human Serum Anti-SARS-CoV-2 (B.1.1.7) Antibody IgG Titer Serologic Assay Kit (Spike RBD)

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RAS-T027 Alpha (B.1.1.7)
Spike protein
Human Serum Anti-SARS-CoV-2 (B.1.1.7) Antibody IgG Titer Serologic Assay Kit (Spike Protein)

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RAS-T029 Beta (B.1.351)
Spike RBD
Human Serum Anti-SARS-CoV-2 (B.1.351) Antibody IgG Titer Serologic Assay Kit (Spike RBD)

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RAS-T030 Beta (B.1.351)
Spike protein
Human Serum Anti-SARS-CoV-2 (B.1.351) Antibody IgG Titer Serologic Assay Kit (Spike Protein)

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RAS-T032 Gamma (P.1)
Spike RBD
Human Serum Anti-SARS-CoV-2 (P.1) Antibody IgG Titer Serologic Assay Kit (Spike RBD)

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RAS-T033 Gamma (P.1)
Spike protein
Human Serum Anti-SARS-CoV-2 (P.1) Antibody IgG Titer Serologic Assay Kit (Spike Protein)

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RAS-T057

SARS-CoV-2

   OmicronNEW B.1.1.529

Human Serum Anti-SARS-CoV-2 (B.1.1.529) Antibody IgG Titer Serologic Assay Kit (Spike RBD)

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RAS-T058 Human Serum Anti-SARS-CoV-2 (B.1.1.529) Antibody IgG Titer Serologic Assay Kit (Spike Trimer))

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RAS-T069 Human Serum Anti-SARS-CoV-2 (B.1.1.529) Total Antibody Titer Serologic Assay Kit (Spike RBD)

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验证数据
检测示例数据

接种疫苗后的血清用新冠抗体滴度检测试剂盒(Cat.No.RAS-T024)进行验证,可准确测试血清中抗体滴度。经检测,试剂盒批间精密度<10%, 批内精密度:<15%。

Protocol

WHO血清标定结果

Protocol

经WHO国际标准血清(G,NIBSC code 20/136 )标定的试剂盒 (Cat.No. RAS-T048 )可用于新冠疫苗接种后血清样本中的IgG抗体的定量检测等,能够显著提高相关指标检测的效率和准确度,是对现有方式的重要补充。

Protocol

便捷高通量中和抗体检测替代方案——特异性中和抗体滴度试剂盒(竞争法ELISA)

可溯源至WHO国际标准血清 (G, NIBSC code 20/136),试剂盒标品与其相关性良好,
检测数据具有实验室间可比性和标准性
与假病毒检测结果相关性好,可作为假病毒中和活性检测的高通量替代方法
操作简单,实验仅需1.5-2h,可同时检测90+样本
提供突变(VOCs)特异性中和抗体检测试剂盒亚搏手机版app下载足球,可特异性识别不同突变
新冠种属 货号 亚搏手机版app下载足球描述 检测样本 订购/预购
SARS-CoV-2
Wild Type
RAS-N022 Anti-SARS-CoV-2 Neutralizing Antibody Titer Serologic Assay Kit Human Serum

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SARS-CoV-2
Alpha | B.1.1.7
RAS-N028 Anti-SARS-CoV-2 (B.1.1.7) Neutralizing Antibody Titer Serologic Assay Kit (Spike RBD) Human Serum

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SARS-CoV-2
Beta | B.1.351
RAS-N031 Anti-SARS-CoV-2 (B.1.351) Neutralizing Antibody Titer Serologic Assay Kit (Spike RBD) Human Serum

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SARS-CoV-2
Gamma | P.1
RAS-N034 Anti-SARS-CoV-2 (P.1) Neutralizing Antibody Titer Serologic Assay Kit (Spike RBD) Human Serum

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SARS-CoV-2
Delta | B.1.617.2
RAS-N040 Anti-SARS-CoV-2 (B.1.617.2) Neutralizing Antibody Serologic Assay Kit (Spike RBD) Human Serum

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RAS-N041 Anti-SARS-CoV-2 (B.1.617.2) Neutralizing Antibody Serologic Assay Kit (Spike Trimer) Human Serum

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SARS-CoV-2

   OmicronNEW B.1.1.529

RAS-N056 Anti-SARS-CoV-2 (B.1.1.529) Neutralizing Antibody Titer Serologic Assay Kit (Spike RBD) Human Serum

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验证数据
实验原理

竞争ELISA法

临床检测数据

接种疫苗后血清验证实验结果表明试剂盒(Cat. No. RAS-N022)对血清样本检测特异性好,准确度高。

假病毒验证

利用RAS-N022试剂盒与假病毒实验对16例康复病人的血清进行中和抗体检测。数据显示,两者具有很高的相关性(R2 =93.73)。

突变特异性结果

56例接种新冠灭活疫苗后血清,用野生型与突变中和抗体检测试剂盒进行检测,Alpha,Beta,Gamma,Delta检测结果均略有降低,其中Beta,Gamma降低较明显。

WHO血清标定结果

注:y = (A - D) / [1 + (x/C)^B] + D (A =1.55562 B =1.45522 C=14.42024 D=0.05532 r^2= 1)

抗体滴度检测金标准必须的关键试剂——新冠Spike蛋白萤光素酶假病毒

病毒原液感染细胞后萤光可达10^6 RLU
不具有复制能力,无致病性
权威性、高灵敏度的中和滴度检测方法
适用于抗体蛋白、血清等的中和效价检测,抑制率可达99%以上
货号 亚搏手机版app下载足球描述 应用 订购/预购
PSSW-HLGB001 SARS-CoV-2 Spike (WT) Fluc-GFP Pseudovirus 新冠病毒(WT)假病毒

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PSSD-HLGB002 SARS-CoV-2 Spike (Delta) Fluc-GFP Pseudovirus 新冠病毒(Delta)假病毒

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PSSO-HLGB003 SARS-CoV-2 Spike (Omicron) Fluc-GFP Pseudovirus 新冠病毒(Omicron)假病毒

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CMO-PAN001 SARS-CoV-2 (WT) Pseudovirus Neutralization Reagents 新冠病毒(WT)假病毒中和检测套装

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CMO-PAN002 SARS-CoV-2 (Delta) Pseudovirus Neutralization Reagents 新冠病毒(Delta)假病毒中和检测套装

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CMO-PAN003 SARS-CoV-2 (Omicron) Pseudovirus Neutralization Reagents 新冠病毒(Omicron)假病毒中和检测套装

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CHEK-ATP042 HEK293/Human ACE2 Overexpression Stable Cell Line 人ACE2过表达细胞株(HEK293)

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真正合格的中和抗体检测质控品——广谱RBD蛋白中和抗体

具备广谱中和活性,可有效中和多种主流突变株
经ELISA验证,特异性及结合活性良好
经假病毒实验验证,对所有VOCs突变株具有广谱中和活性
亚搏手机版app下载足球列表
货号 种属 抗体亚型 亚搏手机版app下载足球描述 订购/预购
S1N-M122 Mouse Human IgG1 Anti-SARS-CoV-2 Spike RBD Neutralizing Antibody, Chimeric mAb, Human IgG1 (AM122)

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SPD-M265 Human Human IgG1 Anti-SARS-CoV-2 Spike RBD Broadly Neutralizing Antibody, Human IgG1

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SPD-M180 Human Human IgG1 Anti-SARS-CoV-2 RBD Potent Neutralizing Antibody, Human IgG1 (AM180)

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SAD-S35 Human Human IgG1 Anti-SARS-CoV-2 Spike RBD Neutralizing Antibody, Human IgG1 (AS35)

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SPD-M128 Mouse Human IgG1 Anti-SARS-CoV-2 RBD Potent Neutralizing Antibody, Chimeric mAb, Human IgG1 (AM128)

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SPD-M162 Mouse Human IgM Anti-SARS-CoV-2 Spike RBD Neutralizing Antibody, Chimeric mAb, Human IgM (AM122)

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SPD-M121 Mouse Human IgG1 Anti-SARS-CoV-2 Spike NTD Neutralizing Antibody, Chimeric mAb, Human IgG1 (AM121)

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S1N-VM226 Mouse Human IgG1 Biotinylated Anti-SARS-CoV-2 Spike RBD Neutralizing Antibody, Chimeric mAb, Human IgG1 (AM122)

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SPD-M201 Cynomolgus Cynomolgus IgG1 Anti-SARS-CoV-2 Spike RBD Neutralizing Antibody, Chimeric mAb, Cynomolgus IgG1 (AM122)

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SPD-M58P1 Mouse Human IgA1 Anti-SARS-CoV-2 Spike RBD Neutralizing Antibody, Chimeric mAb, Human IgA1 (AM122)

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SPD-PM226 Mouse Human IgG1 PE-Labeled Anti-SARS-CoV-2 Spike RBD Neutralizing Antibody, Chimeric mAb, Human IgG1 (AM122)

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SPD-M268 Human Human IgG1 Anti-SARS-CoV-2 RBD Potent Neutralizing Antibody, Human IgG1 (AM268)

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验证数据
>ELISA验证数据

Anti-SARS-CoV-2 Spike RBD Neutralizing antibody (Cat.No.S1N-M122)neutralizes SARS-CoV-2 Spike RBD by inhibiting RBD: ACE2 interaction. The ACE2-coated plate is incubated with the wild type (WT) RBD or B.1.1.7, B.1.351, P.1, B.1.617.1, B.1.617.2 mutant and treated with the neutralizing antibody at increasing concentration. Percent inhibition is calculated based on the OD value.

Protocol

>ELISA验证数据

经假病毒实验体系验证,广谱型中和抗体(Cat.No.S1N-M122) 可以有效中和野生型及Alpha/Beta/Gamma/Delta突变株病毒,适合作为质控品,应用于针对突变株的中和抗体筛选、重组蛋白疫苗临床前及临床研究中的效价检测、血清中的中和抗体检测等。

Protocol

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毒理研究
  • 抗体亚型检测试剂盒

快速获取ADE、VED研究关键结果——便捷高通量IgG抗体亚型检测试剂盒(间接法ELISA)

提供IgG1、IgG2、IgG3、IgG4不同亚型血清学检测用试剂盒
特异性好,可正确分型
亚搏手机版app下载足球稳定性及批间一致性良好
组分配套齐全,操作简单,可同时检测90+样本
货号 亚搏手机版app下载足球描述 检测样本 订购/预购
RAS-T014 Anti-SARS-CoV-2 Antibody IgG1 Titer Serologic Assay kit Human Serum

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RAS-T015 Anti-SARS-CoV-2 Antibody IgG2 Titer Serologic Assay kit Human Serum

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RAS-T016 Anti-SARS-CoV-2 Antibody IgG3 Titer Serologic Assay kit Human Serum

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RAS-T017 Anti-SARS-CoV-2 Antibody IgG4 Titer Serologic Assay kit Human Serum

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RAS-T065 Anti-SARS-CoV-2 (B.1.1.529) Antibody IgG1 Titer Serologic Assay Kit (Spike RBD) Human Serum

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RAS-T066 Anti-SARS-CoV-2 (B.1.1.529) Antibody IgG2 Titer Serologic Assay Kit (Spike RBD) Human Serum

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RAS-T067 Anti-SARS-CoV-2 (B.1.1.529) Antibody IgG3 Titer Serologic Assay Kit (Spike RBD) Human Serum

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RAS-T068 Anti-SARS-CoV-2 (B.1.1.529) Antibody IgG4 Titer Serologic Assay Kit (Spike RBD) Human Serum

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验证数据

Cross-validation data for antibody subtype detection

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